Journal
NEURO-ONCOLOGY
Volume 19, Issue 2, Pages 162-174Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/neuonc/now241
Keywords
brain metastases; chemotherapy; neuroimaging; neuropathology; stereotactic radiosurgery/ stereotactic fractionated radiotherapy; supportive care; surgery; targeted therapy; whole-brain radiation therapy
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The management of patients with brain metastases has become a major issue due to the increasing frequency and complexity of the diagnostic and therapeutic approaches. In 2014, the European Association of NeuroOncology (EANO) created a multidisciplinary Task Force to draw evidence-based guidelines for patients with brain metastases from solid tumors. Here, we present these guidelines, which provide a consensus review of evidence and recommendations for diagnosis by neuroimaging and neuropathology, staging, prognostic factors, and different treatment options. Specifically, we addressed options such as surgery, stereotactic radiosurgery/ stereotactic fractionated radiotherapy, whole-brain radiotherapy, chemotherapy and targeted therapy (with particular attention to brain metastases from non-small cell lung cancer, melanoma and breast and renal cancer), and supportive care.
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