Journal
BRIEFINGS IN BIOINFORMATICS
Volume 19, Issue 6, Pages 1370-1381Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bib/bbx066
Keywords
integrative omics; network approaches; systems biology; computational methods
Funding
- National Institutes of Health [R01 EB022574, R01 LM011360, U01 AG024904, R01 AG19771, P30 AG10133, R01 CA129769, UL1 TR001108, K01 AG049050]
- Department of Defense [W81XWH-14-2-0151, W81XWH-13-1-0259, W81XWH-12-2-0012]
- National Collegiate Athletic Association [14132004]
- Indiana University Network Science Institute (IUNI)
- Alzheimer's Association
- Indiana Clinical and Translational Science Institute
- Indiana University/IU Health Strategic Neuroscience Research Initiative
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In the past decade, significant progress has been made in complex disease research across multiple omics layers from genome, transcriptome and proteome to metabolome. There is an increasing awareness of the importance of biological interconnections, and much success has been achieved using systems biology approaches. However, because of the typical focus on one single omics layer at a time, existing systems biology findings explain only a modest portion of complex disease. Recent advances in multi-omics data collection and sharing present us new opportunities for studying complex diseases in amore comprehensive fashion, and yet simultaneously create new challenges considering the unprecedented data dimensionality and diversity. Here, our goal is to review extant and emerging network approaches that can be applied across multiple biological layers to facilitate amore comprehensive and integrative multilayered omics analysis of complex diseases.
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