Journal
AGING AND DISEASE
Volume 9, Issue 6, Pages 1165-1184Publisher
INT SOC AGING & DISEASE
DOI: 10.14336/AD.2018.1026
Keywords
Aging; antioxidants; astragalus; autophagy; curcumin; intermittent fasting; neurogenesis; plasma transfusion; physical exercise; resveratrol; senescent cells; senolytics; stem cells; stem cell therapy; telomeres
Categories
Funding
- Department of Defense [W81XWH-14-1-0558, W81XWH-14-1-0572]
- Department of Veterans Affairs Merit Award [I01BX000883]
- Department of Veterans Affairs BLRAMP
- D Research Career Scientist award [1IK6BX003612]
- National Institutes of Health - National Institute of Neurological Disorders and Stroke (NIH-NINDS) [R01NS106907-01]
Ask authors/readers for more resources
The prevalence of age-related diseases is in an upward trend due to increased life expectancy in humans. Age-related conditions are among the leading causes of morbidity and death worldwide currently. Therefore, there is an urgent need to find apt interventions that slow down aging and reduce or postpone the incidence of debilitating age-related diseases. This review discusses the efficacy of emerging anti-aging approaches for maintaining better health in old age. There are many anti-aging strategies in development, which include procedures such as augmentation of autophagy, elimination of senescent cells, transfusion of plasma from young blood, intermittent fasting, enhancement of adult neurogenesis, physical exercise, antioxidant intake, and stem cell therapy. Multiple pre-clinical studies suggest that administration of autophagy enhancers, senolytic drugs, plasma from young blood, drugs that enhance neurogenesis and BDNF are promising approaches to sustain normal health during aging and also to postpone age-related neurodegenerative diseases such as Alzheimer's disease. Stem cell therapy has also shown promise for improving regeneration and function of the aged or Alzheimer's disease brain. Several of these approaches are awaiting critical appraisal in clinical trials to determine their long-term efficacy and possible adverse effects. On the other hand, procedures such as intermittent fasting, physical exercise, intake of antioxidants such as resveratrol and curcumin have shown considerable promise for improving function in aging, some of which are ready for large-scale clinical trials, as they are non-invasive, and seem to have minimal side effects. In summary, several approaches are at the forefront of becoming mainstream therapies for combating aging and postponing age-related diseases in the coming years.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available