Journal
ANNALS OF THE RHEUMATIC DISEASES
Volume 77, Issue 3, Pages 343-347Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/annrheumdis-2017-211996
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Funding
- Australian Rheumatology Association
- Arthritis Australia
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Objectives The Psoriatic Arthritis Impact of Disease (PsAID) Questionnaire is a recently developed patientreported outcome measure (PROM) of disease impact in psoriatic arthritis (PsA). We set out to assess the validity in an independent cohort of patients, estimate the minimally important difference for improvement and explore the potential of individual components of the PsAID in clinical practice. Methods D ata were collected prospectively for a single-centre cohort of patients with PsA. Construct validity was assessed by Spearman correlation with other PROMs and reliability by intraclass correlation coefficient (ICC) at 1 week. Sensitivity to change at 3 months was determined by the standardised response mean (SRM) in those patients with active disease requiring a change in treatment. Results A total of 129 patients (mean +/- SD.age 52.1 +/- 13.3, 57% women, disease duration 10.2 +/- 8 years) completed the baseline questionnaires and assessments. The mean baseline PsAID12 score was 3.92 +/- 2.26 with an ICC of 0.91 (95% CI 0.87 to 0.94). The SE of measurement was 0.51 and the minimal detectable change was 1.41. There was strong correlation (r= 0.70) with most of the PROMs studied and moderate correlation with clinical outcomes (r= 0.400.57). The SRM of the PsAID12 was 0.74 (95% CI 0.45 to 0.97). There was strong correlation with individual PsAID items and their corresponding PROM questionnaires (r= 0.67). Conclusion T he PsAID is a reliable, feasible and discriminative measure in patients with PsA. The good responsiveness of the PsAID and strong correlation of individual items with other PROMS represent an opportunity to reduce questionnaire burden for patients in studies and clinical practice.
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