Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 24, Issue 1, Pages 5-6Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.3356
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Warfarin has been the most widely prescribed anticoagulant for decades. It functions by inhibiting the membrane enzyme vitamin K epoxide reductase (VKOR), but the molecular details of this effect have remained elusive. Two new studies shed light on the warfarin-VKOR interaction. The work has implications for precision medicine and could guide drug discovery.
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