Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 24, Issue 6, Pages 496-498Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.3416
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Funding
- NIH [R37 GM074593]
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Two new studies show that RNA-binding proteins can mediate distinct and beneficial effects to cells by binding to the extensive double-stranded RNA (dsRNA) structures of inverted-repeat Alu elements (IRAlus). One study reports stress-induced export of the 110-kDa isoform of the adenosine deaminase acting on RNA 1 protein (ADAR1p110) to the cytoplasm, where it binds IRAlus so as to protect many mRNAs encoding anti-apoptotic proteins from degradation. The other study demonstrates that binding of the nuclear helicase DHX9 to IRAlus embedded within RNAs minimizes defects in RNA processing.
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