Journal
NATURE REVIEWS RHEUMATOLOGY
Volume 13, Issue 2, Pages 87-99Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrrheum.2016.193
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Funding
- Wellcome Trust Programme [086867/Z/08/Z]
- UK Medical Research Council [MR/K013068/1]
- Arthritis Research UK (Career Progression Fellowship) [20387]
- Arthritis Research UK (Career Development Fellowship) [19909]
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme [677542]
- Sir Henry Dale Fellowship
- Wellcome Trust
- Royal Society [107613/Z/15/Z]
- National Institutes of Health Research
- MRC [MR/K013068/1] Funding Source: UKRI
- Versus Arthritis [19909] Funding Source: researchfish
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The past two decades have witnessed major advancements in the clinical management of inflammatory arthritis, with new treatment strategies in some cases providing a marked improvement in patient outcomes. However, it is widely accepted that current strategies do not provide the 'total therapeutic solution', in view of the proportion of patients who do not respond to therapy, the important incidence of adverse effects and the development of an immune response against antibodies or fusion proteins used therapeutically. Moreover, although some therapeutic approaches can effectively bring about an end to inflammation, mechanisms to promote the recovery and/or repair of damage are required. Harnessing the concepts and mechanisms of the resolution of inflammation is a new approach to the treatment of inflammatory pathologies; this approach could help address the unmet need for new therapeutic approaches that not only control but also revert the course of inflammatory rheumatic diseases.
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