Journal
NATURE REVIEWS RHEUMATOLOGY
Volume 14, Issue 1, Pages 19-31Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrrheum.2017.201
Keywords
-
Categories
Funding
- Japan Agency for Medical Research and Development (AMED)-Core Research for Evolutional Science and Technology (CREST)
- AMED
- Center of Innovation (COI) stream grant from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
- Sports Research Innovation Project (SRIP) grant from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
- Ministry of Health, Labour and Welfare of Japan
Ask authors/readers for more resources
Semaphorins have a well-characterized role in guiding axon repulsion during development; however, the important contribution of these proteins in immunity is becoming increasingly clear. Immunoregulatory semaphorins, termed 'immune semaphorins', have roles in regulating immune cell activation, differentiation, mobility and migration. These proteins are also intimately associated with the pathogenesis of autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). This Review discusses the pathogenic functions of immune semaphorins, as well as the potential use of these molecules as diagnostic markers and therapeutic targets for the treatment of autoimmune diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available