Journal
NATURE REVIEWS NEUROSCIENCE
Volume 18, Issue 1, Pages 20-30Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn.2016.162
Keywords
-
Categories
Funding
- Deutsche Forschungsgemeinschaft (DFG) [SFB1158]
- European Research Council (ERC) [294293, 230249]
- EcTop3
Ask authors/readers for more resources
Chronic pain is not simply a temporal continuum of acute pain. Studies on functional plasticity in neural circuits of pain have provided mechanistic insights and linked various modulatory factors to a change in perception and behaviour. However, plasticity also occurs in the context of structural remodelling and reorganisation of synapses, cells and circuits, potentially contributing to the long-term nature of chronic pain. This Review discusses maladaptive structural plasticity in neural circuits of pain, spanning multiple anatomical and spatial scales in animal models and human patients, and addresses key questions on structure function relationships.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available