Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 18, Issue 3, Pages 175-186Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrm.2016.171
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Funding
- US National Institutes of Health [CA181090, AG016642, K99CA212290]
- STARR Cancer Consortium
- Breast Cancer Research Foundation
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The shortening of human telomeres has two opposing effects during cancer development. On the one hand, telomere shortening can exert a tumour-suppressive effect through the proliferation arrest induced by activating the kinases ATM and ATR at unprotected chromosome ends. On the other hand, loss of telomere protection can lead to telomere crisis, which is a state of extensive genome instability that can promote cancer progression. Recent data, reviewed here, provide new evidence for the telomere tumour suppressor pathway and has revealed that telomere crisis can induce numerous cancer-relevant changes, including chromothripsis, kataegis and tetraploidization.
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