Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 18, Issue 3, Pages 159-174Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm.2016.152
Keywords
-
Categories
Funding
- US National Institutes of Health (NIH) predoctoral National Research Service Award (NRSA) from the National Institute of General Medical Sciences [IG31GM113397-01A1]
- NIH postdoctoral NRSA from the National Heart, Lung, and Blood Institute [5T32HL007731-20]
- NIH from the National Cancer Institute [R01CA020535]
- NIH from the National Institute of Diabetes and Digestive and Kidney Diseases [R01DK095750]
- American Heart Association (AHA) [14GRNT20460124]
- W.M. Keck Foundation Medical Research Grant
- National Institute of Environmental Health Sciences [R21E5026068]
- National Science Foundation [MCB-1615826]
Ask authors/readers for more resources
The glucocorticoid receptor (GR) is a constitutively expressed transcriptional regulatory factor (TRF) that controls many distinct gene networks, each uniquely determined by particular cellular and physiological contexts. The precision of GR-mediated responses seems to depend on combinatorial, context-specific assembly of GR-nucleated transcription regulatory complexes at genomic response elements. In turn, evidence suggests that context-driven plasticity is conferred by the integration of multiple signals, each serving as an allosteric effector of GR conformation, a key determinant of regulatory complex composition and activity. This structural and mechanistic perspective on GR regulatory specificity is likely to extend to other eukaryotic TRFs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available