Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 18, Issue 7, Pages 437-451Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrm.2017.27
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Funding
- Junior Faculty Development Award from The University of North Carolina at Chapel Hill
- Nutrition Obesity Research Center (NORC) Pilot and Feasibility Grant from The University of North Carolina at Chapel Hill [P30DK056350]
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Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate vast protein diversity from a limited number of genes. The mechanisms and outcomes of alternative splicing of individual transcripts are relatively well understood, and recent efforts have been directed towards studying splicing networks. It has become apparent that coordinated splicing networks regulate tissue and organ development, and that alternative splicing has important physiological functions in different developmental processes in humans.
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