Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 18, Issue 12, Pages 717-727Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrm.2017.101
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Funding
- US Defense Advanced Research Projects Agency (DARPA) [W911NF-16-1-0551]
- National Science Foundation (NSF) [1651995]
- US Office of Naval Research [N00014-17-1-2147]
- Mechanobiology Institute, Singapore
- MOE, Singapore
- Italian Foundation for Cancer Research (FIRC) Institute of Molecular Oncology (IFOM), Milan, Italy
- Direct For Mathematical & Physical Scien
- Division Of Mathematical Sciences [1651995] Funding Source: National Science Foundation
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It is well established that cells sense chemical signals from their local microenvironment and transduce them to the nucleus to regulate gene expression programmes. Although a number of experiments have shown that mechanical cues can also modulate gene expression, the underlying mechanisms are far from clear. Nevertheless, we are now beginning to understand how mechanical cues are transduced to the nucleus and how they influence nuclear mechanics, genome organization and transcription. In particular, recent progress in super-resolution imaging, in genome-wide application of RNA sequencing, chromatin immunoprecipitation and chromosome conformation capture and in theoretical modelling of 3D genome organization enables the exploration of the relationship between cell mechanics, 3D chromatin configurations and transcription, thereby shedding new light on how mechanical forces regulate gene expression.
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