Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 18, Issue 8, Pages 477-494Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm.2017.36
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Funding
- Max Planck Society
- European Research Council (ERC) [311546]
- Deutsche Forschungsgemeinschaft [SFB 834]
- Excellence Cluster Cardiopulmonary System [EXC 147/1]
- LOEWE grant Ub-Net
- DZHK (German Center for Cardiovascular Research)
- Stiftung Charite
- European Molecular Biology Organization Young Investigator Programme
- Swedish Research Council
- Swedish Cancer Foundation
- European Research Council [ERC-2014-CoG-646849]
- Knut and Alice Wallenberg Foundation
- European Research Council (ERC) [311546] Funding Source: European Research Council (ERC)
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Blood and lymphatic vessels pervade almost all body tissues and have numerous essential roles in physiology and disease. The inner lining of these networks is formed by a single layer of endothelial cells, which is specialized according to the needs of the tissue that it supplies. Whereas the general mechanisms of blood and lymphatic vessel development are being defined with increasing molecular precision, studies of the processes of endothelial specialization remain mostly descriptive. Recent insights from genetic animal models illuminate how endothelial cells interact with each other and with their tissue environment, providing paradigms for vessel type- and organ-specific endothelial differentiation. Delineating these governing principles will be crucial for understanding how tissues develop and maintain, and how their function becomes abnormal in disease.
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