Journal
NATURE REVIEWS MICROBIOLOGY
Volume 16, Issue 1, Pages 5-11Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro.2017.73
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Funding
- Netherlands Organization of Scientific Research (NWO-ECHO grant) [711013002]
- Netherlands Organization of Scientific Research (NWO-TOP grant) [714015001]
- European Molecular Biology Organization (EMBO) [ALTF 179-2015]
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Argonaute proteins constitute a highly diverse family of nucleic acid-guided proteins. They were first discovered in eukaryotes as key proteins in RNA interference systems, but homologous prokaryotic Argonaute proteins (pAgos) have also been found in archaea and bacteria. In this Progress article, we focus on long pAgo variants, a class of pAgos that are involved in nucleic acid-guided host defence against invading nucleic acids, and discuss the potential of pAgos in genome editing.
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