Journal
NATURE REVIEWS GENETICS
Volume 18, Issue 3, Pages 192-208Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrg.2016.157
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Funding
- la Ligue Nationale contre le Cancer (Equipe labellisee Ligue)
- European Commission Network of Excellence EpiGeneSys [HEALTH-F4-2010-257082]
- European Research Council [2009-AdG_20090506]
- European Commission [FP7_HEALTH-2010-259743]
- French National Research Agency (ANR) [ANR-10-BLAN-1326-03, ANR-11-LABX-0044_DEEP, ANR-10-IDEX-0001-02 PSL, ANR-12-BSV5-0022-02]
- Aviesan Instituts thematiques multi-organismes (Aviesan-ITMO) cancer project 'Epigenomics of breast cancer'
- Marie Curie Initial Training Network (Nucleosome 4D)
- La Fondation pour la recherche medicale
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Centromeric chromatin undergoes major changes in composition and architecture during each cell cycle. These changes in specialized chromatin facilitate kinetochore formation in mitosis to ensure proper chromosome segregation. Thus, proper orchestration of centromeric chromatin dynamics during interphase, including replication in S phase, is crucial. We provide the current view concerning the centromeric architecture associated with satellite repeat sequences in mammals and its dynamics during the cell cycle. We summarize the contributions of deposited histone variants and their chaperones, other centromeric components - including proteins and their post-translational modifications, and RNAs - and we link the expression and deposition timing of each component during the cell cycle. Because neocentromeres occur at ectopic sites, we highlight how cell cycle processes can go wrong, leading to neocentromere formation and potentially disease.
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