Journal
NATURE REVIEWS GENETICS
Volume 18, Issue 7, Pages 425-440Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrg.2017.19
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- Spanish Ministry of Economy and Competitiveness, 'Centro de Excelencia Severo Ochoa' of the Centres de Recerca de Catalunya Programme/Generalitat de Catalunya
- Programa de Ayudas Formacion de Personal investigador (FPI) del Ministerio de Economia y Competitividad [BES-2012-055848]
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Cross-species comparisons of genomes, transcriptomes and gene regulation are now feasible at unprecedented resolution and throughput, enabling the comparison of human and mouse biology at the molecular level. Insights have been gained into the degree of conservation between human and mouse at the level of not only gene expression but also epigenetics and inter-individual variation. However, a number of limitations exist, including incomplete transcriptome characterization and difficulties in identifying orthologous phenotypes and cell types, which are beginning to be addressed by emerging technologies. Ultimately, these comparisons will help to identify the conditions under which the mouse is a suitable model of human physiology and disease, and optimize the use of animal models.
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