Journal
NATURE REVIEWS GENETICS
Volume 19, Issue 1, Pages 34-49Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg.2017.74
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Funding
- A*STAR Investigatorship [1437a00119, 1437a00117]
- Sofja Kovaleskaja Award from Humboldt Foundation
- Canadian Institutes of Health Research [MOP-142375]
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Gene essentiality is a founding concept of genetics with important implications in both fundamental and applied research. Multiple screens have been performed over the years in bacteria, yeasts, animals and more recently in human cells to identify essential genes. A mounting body of evidence suggests that gene essentiality, rather than being a static and binary property, is both context dependent and evolvable in all kingdoms of life. This concept of a non-absolute nature of gene essentiality changes our fundamental understanding of essential biological processes and could directly affect future treatment strategies for cancer and infectious diseases.
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