Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 16, Issue 7, Pages 441-442Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd.2017.78
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Funding
- Cancer Research UK [18176] Funding Source: researchfish
- The Francis Crick Institute [C50947/A18176] Funding Source: researchfish
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Tumour evolution, which results in the existence of multiple distinct populations of cancer cells within the same tumour and the same patient, is increasingly appreciated to have a key role in drug resistance. In this article, we discuss the implications for drug development, including approaches to reduce the likelihood of the emergence of drug resistance.
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