Journal
NATURE REVIEWS CARDIOLOGY
Volume 14, Issue 11, Pages 635-636Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrcardio.2017.156
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Funding
- University of Oxford
- UK Medical Research Council
- University of Bristol
- UK Medical Research Council [MC_UU_12013/1]
- MRC [MC_UU_12013/1] Funding Source: UKRI
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Initial randomized trials of cholesteryl ester transfer protein (CETP) inhibitors were terminated early owing to adverse effects or futility. The REVEAL trial now shows the benefit of CETP inhibition in coronary heart disease. Despite raising HDL-cholesterol levels, the cardiovascular effect of CETP inhibitors is probably due to lowering of non-HDL-cholesterol levels.
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