Journal
ACS APPLIED NANO MATERIALS
Volume 1, Issue 11, Pages 6312-6319Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsanm.8b01533
Keywords
combination therapy; organic nanoparticles; phototrigger; photodynamic therapy; drug delivery
Funding
- DST SERB [EMR/2016/005885]
- DST [SR/FST/CSII-026/2013]
- UGC-New Delhi
- Indian Institute of Technology Kharagpur
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In this paper, we have developed photo responsive fluorescent organic nanoconjugates based on a single-component system for effective cancer treatment by a synergistic combination of photodynamic therapy (PDT) and chemotherapy. Our single-component system was synthesized by coupling the squaric acid and the coumarin-chlorambucil conjugate. Next, multifunctional squaric acid-coumarinchlorambucil (Sq-Cou-Cbl) nanoconjugates were prepared by simple reprecipitation technique. The unique properties of the newly designed Sq-Cou-Cbl nanoconjugates are (i) a phototrigger for controlled anticancer drug (chlorambucil) release and a photosensitizer for PDT upon visible light irradiation (ii) cellular imaging and self-monitoring of the drug release by a noninvasive fluorescent technique and (iii) PDT activity of the released photoproduct thereby resulting in the improved therapeutic efficiency. Further, in vitro studies showed that Sq-CouCbl nanoconjugates exhibited an enhanced anticancer activity by synergistic cytotoxic effect of PDT and chemotherapy on HeLa cells.
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