Journal
NATURE NEUROSCIENCE
Volume 20, Issue 9, Pages 1213-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4606
Keywords
-
Categories
Funding
- NIH [5T32GM007592, R01DE022901, S10OD010650]
- Foundation of Anesthesia Research and Education
- Hangzhou Science and Technology Plan [20130633B02]
- Zhejiang Medical Science and Technology Plan [2011KYB064]
Ask authors/readers for more resources
Chemotherapy-induced pain is a dose-limiting condition that affects 30% of patients undergoing chemotherapy. We found that gut microbiota promotes the development of chemotherapy-induced mechanical hyperalgesia. Oxaliplatin-induced mechanical hyperalgesia was reduced in germ-free mice and in mice pretreated with antibiotics. Restoring the microbiota of germ-free mice abrogated this protection. These effects appear to be mediated, in part, by TLR4 expressed on hematopoietic cells, including macrophages.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available