Journal
NATURE NEUROSCIENCE
Volume 20, Issue 7, Pages 960-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4566
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Funding
- Marie Curie IEF
- EMBO LTF
- Boehringer Ingelheim Fonds PhD fellowship
- Human Frontier Science Program Postdoctoral Fellowship
- Ambizione Fellowship
- Swiss National Science Foundation
- European Research Council
- National Centres of Competence in Research Molecular Systems Engineering
- Swiss National Science Foundation Sinergia
- Swiss-Hungarian grant
- DARPA
- European Union
- European Research Council Advanced Grant NeuroCMOS [AdG 267351]
- Swiss National Science Foundation Sinergia Project [CRSII3_141801]
- Swiss National Science Foundation (SNF) [CRSII3_141801] Funding Source: Swiss National Science Foundation (SNF)
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How neuronal computations in the sensory periphery contribute to computations in the cortex is not well understood. We examined this question in the context of visual-motion processing in the retina and primary visual cortex ( V1) of mice. We disrupted retinal direction selectivity, either exclusively along the horizontal axis using FRMD7 mutants or along all directions by ablating starburst amacrine cells, and monitored neuronal activity in layer 2/3 of V1 during stimulation with visual motion. In control mice, we found an over-representation of cortical cells preferring posterior visual motion, the dominant motion direction an animal experiences when it moves forward. In mice with disrupted retinal direction selectivity, the over-representation of posterior-motion-preferring cortical cells disappeared, and their responses at higher stimulus speeds were reduced. This work reveals the existence of two functionally distinct, sensory-periphery-dependent and -independent computations of visual motion in the cortex.
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