Journal
NATURE NEUROSCIENCE
Volume 20, Issue 9, Pages 1209-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4612
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Funding
- New York Stem Cell Foundation
- Maryland Stem Cell Research Funding (MSCRF)
- NIH [R01NS093213, R01MH105128, R35NS097370, U19AI131130, U19MH106434, P01NS097206, R37NS047344, R21AI119530]
- National Natural Science Foundation of China [31430037]
- Chinese Academy of Sciences [QYZDJ-SSW-SMC007]
- Shanghai Brain-Intelligence Project from STCSM [16JC1420500]
- Beijing Brain Project [Z161100002616004]
- FSU Zika seed funding
- Adelson Medical Research Foundation
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Zika virus (ZIKV) infection is associated with neurological disorders of both the CNS and peripheral nervous systems (PNS), yet few studies have directly examined PNS infection. Here we show that intraperitoneally or intraventricularly injected ZIKV in the mouse can infect and impact peripheral neurons in vivo. Moreover, ZIKV productively infects stemcell- derived human neural crest cells and peripheral neurons in vitro, leading to increased cell death, transcriptional dysregulation and cell-type-specific molecular pathology.
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