Journal
NATURE NEUROSCIENCE
Volume 20, Issue 3, Pages 389-392Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4483
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Funding
- Spanish Ministry of Education, Culture and Sport [EX2009-0750]
- postdoctoral contract from Junta de Andalucia [P12-CTS-2232]
- [EY023871]
- [R01 EY018322]
- [R01 EB022915]
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Push-pull is a canonical computation of excitatory cortical circuits. By contrast, we identify a pull-push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP)-expressing interneurons. During arousal, VIP cells rapidly and directly inhibit pyramidal neurons; VIP cells also indirectly excite these pyramidal neurons via parallel disinhibition. Thus, arousal exerts a feedback pull-push influence on excitatory neurons-an inversion of the canonical push-pull of feedforward input.
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