Journal
ACS APPLIED NANO MATERIALS
Volume 1, Issue 4, Pages 1811-1818Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsanm.8b00219
Keywords
graphene oxide; polyethylenimine; antibacterial; synergistic effect; methicillin-resistant Staphylococcus aureus
Funding
- Research Grants Council of Hong Kong [PolyU 153012/14P]
- PolyU Grants [1-ZVGH, 1-BBAD]
- [C7038-15G]
- [C5026-16G]
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An aqueous dispersion of polyethylenimine-modified graphene oxide (PEI-GO) was prepared via a one-step synthesis through an epoxy ring opening reaction. PEI-GO exhibited bacterial growth inhibition activity on methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration as low as 8 mu g mL(-1). Time-kill curve assay and SYTOX Green assay showed the antibacterial activity and bacteria cell membrane permeability of PEI-GO, respectively. Most importantly, when PEI-GO was employed at 1-2 mu g mL(-1), a synergistic effect with daptomycin to resensitize daptomycin-resistant MRSA was revealed. A synergistic effect between PEI-GO and daptomycin provides a possible way to increase bacterial killing and reduce the development of daptomycin resistance. The antibacterial activity of PEI-GO is attributed to the damaged cell membrane caused by the sharp edge and chain structure of the PEI-GO nanosheets as well as the high density of amine groups present in the PEI chains. Our results indicate that PEI-GO dispersion has a treatment.
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