Journal
ACS APPLIED NANO MATERIALS
Volume 1, Issue 5, Pages 2294-2305Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsanm.8b00359
Keywords
dual-modality imaging photothermal therapy; atom-transfer radical polymerization; near-infrared; diagnosis and treatment
Funding
- National Natural Science Foundation of China [51573039]
Ask authors/readers for more resources
Dual-modality-imaging-guided photothermal therapy (PTT) exhibits great potential in the field of diagnosis and treatment. Herein, we report a controllable method (atom-transfer radical polymerization) for the preparation of gadolinium(III)-complex-grafted lead sulfide (GCGLS) nanoparticles. A series of characterizations (such as TEM, HR-TEM, EDX, XRD, FTIR, etc.) prove that GCGLS nanoparticles have been successfully prepared. The GCGLS nanoparticles with ultrasmall sizes (ca. 11 nm) have quite strong photoabsorption intensity in the near-infrared (NIR) region because of a low S vacancy concentration of lead sulfide. As the addition amount of gadolinium(III) complexes increases, the sizes of the GCGLS nanoparticles show no evidence of changing. The temperature of the GCGLS nanoparticle solution can quickly elevate to 57.5 degrees C in 10 min after NIR laser irradiation (1.5 W cm(-2)) at 808 nm; this result reveals that it possesses high photothermal conversion efficiency (similar to 31%). When the GCGLS nanoparticles are injected into the mice, it is clearly observed that there is efficient accumulation in the tumor site. Moreover, the GCGLS nanoparticles also show excellent prominent X-ray computer tomography (CT) and T-1-weighted magnetic resonance (T-1-MR) imaging in vitro/vivo. By the combination of GCGLS and NIR laser irradiation, an effective tumor treatment experiment is conducted in mice. Therefore, the prepared GCGLS nanoparticles with dual-modality-imaging-guided PTT can be used as potential diagnosis and treatment reagents for clinical applications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available