Journal
NATURE NEUROSCIENCE
Volume 20, Issue 2, Pages 260-270Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn.4470
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Funding
- EMBL
- ERC
- Swiss National Science Foundation
- Wellcome Trust/Royal Society Henry Dale Fellowship [098400/Z/12/Z]
- Medical Research Council (MRC) [MC-UP-1201/1]
- Marie Sklodowska-Curie grant [659842]
- University of Zurich, Forschungskredit
- One Hundred Talents Program of CAS
- Shenzhen city government [JCYJ20140901003938992, KQCX2015033117354153]
- Medical Research Council [MC_UP_1201/1] Funding Source: researchfish
- Marie Curie Actions (MSCA) [659842] Funding Source: Marie Curie Actions (MSCA)
- MRC [MC_UP_1201/1] Funding Source: UKRI
- Wellcome Trust [098400/Z/12/Z] Funding Source: Wellcome Trust
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The prefrontal cortex helps adjust an organism's behavior to its environment. In particular, numerous studies have implicated the prefrontal cortex in the control of social behavior, but the neural circuits that mediate these effects remain unknown. Here we investigated behavioral adaptation to social defeat in mice and uncovered a critical contribution of neural projections from the medial prefrontal cortex to the dorsal periaqueductal gray, a brainstem area vital for defensive responses. Social defeat caused a weakening of functional connectivity between these two areas, and selective inhibition of these projections mimicked the behavioral effects of social defeat. These findings define a specific neural projection by which the prefrontal cortex can control and adapt social behavior.
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