Journal
NATURE NANOTECHNOLOGY
Volume 12, Issue 8, Pages 763-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NNANO.2017.69
Keywords
-
Funding
- James C. and Sara K. Kennedy Award from Mayo Clinic
- Jorge and Leslie Bacardi Fund for the study of Regenerative Medicine, Mayo Clinic Center for Regenerative Medicine
- Mayo Clinic Center for Individualized Medicine Gerstner Family Award
- Helene Houle Mayo Clinic Career Development Award in Neurologic Surgery
- Mayo Clinic Neuroregenerative Medicine Initiative for Neuro-Oncology Research
- China Scholarships Council [201406100114]
- DeMars Family Mayo Clinic Development Fund
- Strawn Family Mayo Clinic Development Fund
Ask authors/readers for more resources
Tumour-targeted immunotherapy offers the unique advantage of specific tumouricidal effects with reduced immune-associated toxicity(1,2). However, existing platforms suffer from low potency, inability to generate long-term immune memory and decreased activities against tumour-cell subpopulations with low targeting receptor levels(3-5). Here we adopted a modular design approach that uses colloidal nanoparticles as substrates to create a multivalent bi-specific nanobioconjugate engager (mBiNE) to promote selective, immune-mediated eradication of cancer cells. By simultaneously targeting the human epidermal growth factor receptor 2 (HER2) expressed by cancer cells(6) and pro-phagocytosis signalling mediated by calreticulin(7), the mBiNE stimulated HER2-targeted phagocytosis and produced durable antitumour immune responses against HER2-expressing tumours. Interestingly, although the initial immune activation mediated by the mBiNE was receptor dependent, the subsequent antitumour immunity also generated protective effects against tumour-cell populations that lacked the HER2 receptor. Thus, the mBiNE represents a new targeted, nanomaterial-immunotherapy platform to stimulate innate and adaptive immunity and promote a universal antitumour response.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available