Journal
NATURE METHODS
Volume 14, Issue 4, Pages 411-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.4189
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Funding
- National Human Genome Research Institute of the US National Institutes of Health [HG006321, HG007827, 5U54HG007990]
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DNA chemical modifications regulate genomic function. We present a framework for mapping cytosine and adenosine methylation with the Oxford Nanopore Technologies MinION using this nanopore sequencer's ionic current signal. We map three cytosine variants and two adenine variants. The results show that our model is sensitive enough to detect changes in genomic DNA methylation levels as a function of growth phase in Escherichia coli.
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