Journal
NATURE METHODS
Volume 14, Issue 6, Pages 581-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.4290
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Funding
- NIH [1U01N5094341-01]
- Purdue University
- NRF [2016R1C1B2015130]
- NSFC [61327902]
- National Research Foundation of Korea [2016R1C1B2015130] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Adaptive optics can correct for optical aberrations. We developed multi-pupil adaptive optics (MPAO), which enables simultaneous wavefront correction over a field of view of 450 x 450 m2 and expands the correction area to nine times that of conventional methods. MPAO's ability to perform spatially independent wavefront control further enables 3D nonplanar imaging. We applied MPAO to in vivo structural and functional imaging in the mouse brain.
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