Journal
NATURE METHODS
Volume 14, Issue 9, Pages 865-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/NMETH.4380
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Funding
- Deutsche Forschungsgemeinschaft
- NIH [DP2-HG-009623]
- National Human Genome Research Institute [UM1HG008901]
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High-throughput single-cell RNA sequencing has transformed our understanding of complex cell populations, but it does not provide phenotypic information such as cell-surface protein levels. Here, we describe cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq), a method in which oligonucleotide-labeled antibodies are used to integrate cellular protein and transcriptome measurements into an efficient, single-cell readout. CIT-seq is compatible with existing single-cell sequencing approaches and scales readily with throughput increases.
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