Journal
NATURE METHODS
Volume 14, Issue 7, Pages 699-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nmeth.4298
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Funding
- NIH [U54CA149145, R01MH101814, R01HG008150, R01MH101820, 1R01MH109905-01, 1R01GM120167-010]
- CIHR Neuroinflammation fellowship
- Ontario Ministry of Research and Innovation
- Searle Scholars Program
- Edward Mallinckrodt Jr. Foundation
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Identifying interactions between genetics and the environment (GxE) remains challenging. We have developed EAGLE, a hierarchical Bayesian model for identifying GxE interactions based on associations between environmental variables and allele-specific expression. Combining whole-blood RNA-seq with extensive environmental annotations collected from 922 human individuals, we identified 35 GxE interactions, compared with only four using standard GxE interaction testing. EAGLE provides new opportunities for researchers to identify GxE interactions using functional genomic data.
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