Journal
NATURE MEDICINE
Volume 23, Issue 2, Pages 151-163Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.4269
Keywords
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Funding
- NIH/NINDS [R01 NS076054, 5T32NS041234]
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Alterations in a-synuclein dosage lead to familial Parkinson's disease (PD), and its accumulation results in synucleinopathies that include PD, dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Furthermore, alpha-synuclein contributes to the fibrilization of amyloid-beta and tau, two key proteins in Alzheimer's disease, which suggests a central role for alpha-synuclein toxicity in neurodegeneration. Recent studies of factors contributing to alpha-synuclein toxicity and its disruption of downstream cellular pathways, have expanded our understanding of disease pathogenesis in synucleinopathies.
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