Journal
NATURE MEDICINE
Volume 23, Issue 6, Pages 678-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm.4330
Keywords
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Funding
- NIH-NINDS [R25-NS065743, U01-NS090362, R01-NS029709]
- Massachusetts General Hospital Executive Committee on Research
- Citizens United for Research in Epilepsy
- Blue Bird Circle Foundation
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We directly assessed mesial temporal activity using intracranial foramen ovale electrodes in two patients with Alzheimer's disease (AD) without a history or EEG evidence of seizures. We detected clinically silent hippocampal seizures and epileptiform spikes during sleep, a period when these abnormalities were most likely to interfere with memory consolidation. The findings in these index cases support a model in which early development of occult hippocampal hyperexcitability may contribute to the pathogenesis of AD.
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