Journal
NATURE GENETICS
Volume 49, Issue 3, Pages 403-415Publisher
NATURE PORTFOLIO
DOI: 10.1038/ng.3768
Keywords
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Categories
Funding
- National Institute for Health Research (NIHR) as part of the portfolio of translational research of the NIHR Biomedical Research Unit at Barts and The London School of Medicine and Dentistry
- NIHR Imperial College Health Care NHS Trust and Imperial College London Biomedical Research Centre
- China Scholarship Council [2011632047]
- UK Medical Research Council [G0800270, MR/N015746/1]
- British Heart Foundation [SP/09/002, SP/13/2/30111]
- UK National Institute for Health Research Cambridge Biomedical Research Centre
- European Research Council [268834]
- European Commission Framework Programme 7 [HEALTH-F2-2012-279233]
- MRC Unit at the University of Bristol [MC_UU_12013/1-9]
- NHLBI
- National Institutes of Health [HL113933, HL124262, HL128782, HL086694]
- ZonMw [90.700.441]
- Marie Sklodowska-Curie GF [H2020-MSCA-IF-2014, 661395]
- Marie Sklodowska-Curie GF grant [661395]
- ICIN-NHI
- UK National Institute for Health Research Biomedical Research Centre at Imperial College Healthcare NHS Trust
- NIHR Biomedical Research Centre at Imperial College Healthcare NHS Trust and Imperial College London
- Wellcome Trust [109863/Z/15/Z]
- EU PhenoMeNal project (Horizon) [654241]
- Wellcome Trust core award [090532/Z/09/Z]
- BHF Centre of Research Excellence, Oxford [RE/13/1/30181]
- MRC core grant for QTL in Health and Disease programme
- NIHR Health Protection Research Unit in Health Impact of Environmental Hazards [HPRU-2012-10141]
- Public Health England [MR/L01341X/1]
- Medical Research Council [MR/L01632X/1]
- [MR/L016311/1]
- Marie Curie Actions (MSCA) [661395] Funding Source: Marie Curie Actions (MSCA)
- BBSRC [BB/F019394/1] Funding Source: UKRI
- MRC [G0800270, G0600237, MC_UU_12015/1, MR/L01632X/1, MR/L01341X/1, MR/N015746/1, MC_PC_U127561128, MC_UU_12013/3, MR/L003120/1, MR/L016311/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F019394/1] Funding Source: researchfish
- British Heart Foundation [PG/16/49/32176, RG/15/12/31616, RG/08/014/24067, SP/13/2/30111] Funding Source: researchfish
- Chief Scientist Office [CZD/16/6/4] Funding Source: researchfish
- Medical Research Council [MR/L01341X/1, MC_qA137853, MR/L003120/1, MC_UU_12013/3, G0600237, MR/K026992/1, MR/N015746/1, MC_UU_12015/1, G0800270, MR/K006584/1, MC_PC_U127561128, MR/L01632X/1, MR/L016311/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0611-10170, NF-SI-0512-10165, NF-SI-0513-10059, NF-SI-0611-10136, NF-SI-0507-10228, NF-SI-0514-10027, NF-SI-0512-10113] Funding Source: researchfish
- Wellcome Trust [109863/Z/15/Z] Funding Source: Wellcome Trust
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Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure-raising genetic variants on future cardiovascular disease risk.
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