Journal
NATURE GENETICS
Volume 50, Issue 1, Pages 42-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41588-017-0014-7
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Funding
- MRC [G0601361, MC_UU_12015/1, G0401540, MR/K002449/2, MR/K002449/1] Funding Source: UKRI
- Lundbeck Foundation [R163-2013-16235] Funding Source: researchfish
- Medical Research Council [MC_PC_13048] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0617-10149, NF-SI-0512-10135, NF-SI-0515-10016] Funding Source: researchfish
- Wellcome Trust [096964/Z/11/Z] Funding Source: researchfish
- Asthma UK [MRC-Asthma UK Centre] Funding Source: researchfish
- NATIONAL CANCER INSTITUTE [P01CA196569] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [RC2HL101651, U01HL130114, R01HL077612] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES009089, ZIAES049019, P30ES006694, ZIAES043012] Funding Source: NIH RePORTER
- European Research Council [648916] Funding Source: Medline
- Medical Research Council [G0902125, MR/K002449/1, G0401540, MC_UU_12015/1, G9815508, G0601361, MR/K002449/2] Funding Source: Medline
- NCI NIH HHS [P01 CA196569] Funding Source: Medline
- NHLBI NIH HHS [R01 HL129735, RC2 HL101651, R01 HL077612, U01 HL130114] Funding Source: Medline
- NIEHS NIH HHS [P30 ES009089, P30 ES006694] Funding Source: Medline
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We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.
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