Journal
NATURE CHEMICAL BIOLOGY
Volume 13, Issue 5, Pages 464-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEMBIO.2318
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Funding
- MIT Department of Chemistry
- MIT Deshpande Center for Technological Innovation
- Dr. Reddy's Laboratories Limited
- National Science Foundation Graduate Student Fellowship
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Here we report a fully automated, flow-based approach to solid-phase polypeptide synthesis, with amide bond formation in 7 seconds and total synthesis times of 40 seconds per amino acid residue. Crude peptide purities and isolated yields were comparable to those for standard-batch solid-phase peptide synthesis. At full capacity, this approach can yield tens of thousands of individual 30-mer peptides per year.
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