Journal
NATURE CHEMICAL BIOLOGY
Volume 13, Issue 4, Pages 363-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/nchembio.2314
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Funding
- Lichtenberg Grant of the Volkswagen Foundation [85 701]
- German Federal Ministry of Education and Research [0315450I]
- DFG excellence program CNMBP [DFG-EXC 171]
- Max Planck Society
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In this study, we engineered fatty acid synthases (FAS) for the biosynthesis of short-chain fatty acids and polyketides, guided by a combined in vitro and in silico approach. Along with exploring the synthetic capability of FAS, we aim to build a foundation for efficient protein engineering, with the specific goal of harnessing evolutionarily related megadalton-scale polyketide synthases (PKS) for the tailored production of bioactive natural compounds.
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