Journal
NATURE CHEMICAL BIOLOGY
Volume 13, Issue 11, Pages 1155-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/nchembio.2471
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Funding
- ERASynBio [81861]
- NIGMS [086374]
- UC Berkeley SURF Rose Hills
- DOE Joint BioEnergy Institute - US Department of Energy, Office of Science, Office of Biological and Environmental Research [DE-AC02-05CH11231]
- DOE Joint Genome Institute - US Department of Energy, Office of Science, Office of Biological and Environmental Research [DE-AC02-05CH11231]
- NNF Center for Biosustainability [Synthetic Biology Tools for Yeast] Funding Source: researchfish
- Novo Nordisk Fonden [NNF10CC1016517] Funding Source: researchfish
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cProdiginines, which are tripyrrole alkaloids displaying a wide array of bioactivities, occur as linear and cyclic congeners. Identification of an unclustered biosynthetic gene led to the discovery of the enzyme responsible for catalyzing the regiospecific C-H activation and cyclization of prodigiosin to cycloprodigiosin in Pseudoalteromonas rubra. This enzyme is related to alkylglycerol monooxygenase and unrelated to RedG, the Rieske oxygenase that produces cyclized prodiginines in Streptomyces, implying convergent evolution.
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