Journal
NATURE CHEMICAL BIOLOGY
Volume 13, Issue 4, Pages 366-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.2285
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Funding
- NIH [R37 AI52188, R01 CA203257, U01 GM098248]
- NCATS [UL1TR001998]
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This study highlights the biochemical and structural charact-eri-zation of the L-tryptophan C6 C-prenyltransferase (C-PT) PriB from Streptomyces sp. RM-5-8. PriB was found to be uniquely permissive to a diverse array of prenyl donors and acceptors including daptomycin. Two additional PTs also produced novel prenylated daptomycins with improved antibacterial activities over the parent drug.
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