Journal
NATURE CELL BIOLOGY
Volume 19, Issue 8, Pages 876-882Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb3579
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Funding
- Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases
- National Natural Science Foundation of China (NSFC) [31561143001, 31630048, 31421002]
- National Basic Research Program of China [2013CB910100]
- Strategic Priority Research Program of the Chinese Academy of Sciences (CAS) [XDB19000000]
- Key Research Program of Frontier Sciences, CAS [QYZDY-SSW-SMC006]
- International Early Career Scientist grant from the Howard Hughes Medical Institute
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Understanding organelle biogenesis is a central focus of cell biology. Whereas some are generated from existing organelles, others can be generated de novo. Most de novo organelle biogenesis occurs in the endoplasmic reticulum (ER). Here, we review the role of the ER in the generation of peroxisomes, lipid droplets, and omegasomes, which are platforms for autophagosome production, and discuss how ER subdomains with specific protein and lipid composition form and promote organelle biogenesis.
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