Journal
NATURE CELL BIOLOGY
Volume 19, Issue 4, Pages 306-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb3492
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Funding
- OMAA Ernst Mach Predoctoral Scholarship
- Cancer Research UK [FC001317]
- Spanish Ministry of Economy and Competitiveness 'Centro de Excelencia Severo Ochoa'
- CERCA Programme/Generalitat de Catalunya
- European Union/ERC [306589]
- COLLMOT [227878]
- Francis Crick Institute
- UK Medical Research Council [FC001317]
- Wellcome Trust [FC001317]
- Austrian Science Foundation (FWF) [I930-B20]
- Cancer Research UK [21144] Funding Source: researchfish
- The Francis Crick Institute [10317] Funding Source: researchfish
- European Research Council (ERC) [306589] Funding Source: European Research Council (ERC)
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During embryonic development, mechanical forces are essential for cellular rearrangements driving tissue morphogenesis. Here, we show that in the early zebrafish embryo, friction forces are generated at the interface between anterior axial mesoderm (prechordal plate, ppl) progenitors migrating towards the animal pole and neurectoderm progenitors moving in the opposite direction towards the vegetal pole of the embryo. These friction forces lead to global rearrangement of cells within the neurectoderm and determine the position of the neural anlage. Using a combination of experiments and simulations, we show that this process depends on hydrodynamic coupling between neurectoderm and ppl as a result of E-cadherin-mediated adhesion between those tissues. Our data thus establish the emergence of friction forces at the interface between moving tissues as a critical force-generating process shaping the embryo.
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