Journal
NATURE BIOTECHNOLOGY
Volume 35, Issue 11, Pages 1087-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nbt.3978
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Funding
- Office of Naval Research [N00014-12-1-0631]
- National Science Foundation [MCB-1412459, DMS-1614838]
- Army Research Office [W911NF-14-1-0490]
- National Institutes of Health [1R01-GM098642, K99CA207872-01]
- Swiss National Science Foundation [P300P2_154583]
- David and Lucile Packard Fellowship
- Direct For Mathematical & Physical Scien
- Division Of Mathematical Sciences [0943760] Funding Source: National Science Foundation
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1412459] Funding Source: National Science Foundation
- Swiss National Science Foundation (SNF) [P300P2_154583] Funding Source: Swiss National Science Foundation (SNF)
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Biological systems can generate microstructured materials that combine organic and inorganic components and possess diverse physical and chemical properties. However, these natural processes in materials fabrication are not readily programmable. Here, we use a synthetic-biology approach to assemble patterned materials. We demonstrate programmable fabrication of three-dimensional (3D) materials by printing engineered self-patterning bacteria on permeable membranes that serve as a structural scaffold. Application of gold nanoparticles to the colonies creates hybrid organic-inorganic dome structures. The dynamics of the dome structures' response to pressure is determined by their geometry (colony size, dome height, and pattern), which is easily modified by varying the properties of the membrane (e.g., pore size and hydrophobicity). We generate resettable pressure sensors that process signals in response to varying pressure intensity and duration.
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