Journal
NATURE
Volume 546, Issue 7658, Pages 401-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature22400
Keywords
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Categories
Funding
- NIH [5T32AI007244-33, R35 GM11977401]
- Mahan Postdoctoral Fellowship from the Computational Biology Program at Fred Hutch
- ASTMH Shope Fellowship
- Sir Henry Dale Fellowship [204311/Z/16/Z]
- US NIH MIDAS program [U54-GM088491]
- CDC [U01CK000510]
- EU [278433-PREDEMICS]
- ERC [260864]
- Horizon grant [643476-COMPARE]
- NIH NIAID [U19AI110818, R01AI099210]
- Howard Hughes Medical Institute
- AWS Cloud Credits for Research
- Broad Institute BroadNext10 program
- EU ERC [614725-PATHPHYLODYN]
- USAID Emerging Pandemic Threats Program-2 PREDICT-2 [AID-OAA-A-14-00102]
- DARPA
- NIH NCATS CTSA [UL1TR001114]
- NIAID [HHSN272201400048C]
- Ray Thomas Foundation
- Medical Research Council [MR/M501621/1, MR/L015080/1, MC_PC_15100] Funding Source: researchfish
- CDC
- ALLCDC [6U01CK000510-01M001] Funding Source: Federal RePORTER
- CDC
- ALLCDC [1021631] Funding Source: Federal RePORTER
- MRC [MR/L015080/1, MC_PC_15100] Funding Source: UKRI
Ask authors/readers for more resources
Zika virus (ZIKV) is causing an unprecedented epidemic linked to severe congenital abnormalities(1,2). In July 2016, mosquito-borne ZIKV transmission was reported in the continental United States; since then, hundreds of locally acquired infections have been reported in Florida(3,4). To gain insights into the timing, source, and likely route(s) of ZIKV introduction, we tracked the virus from its first detection in Florida by sequencing ZIKV genomes from infected patients and Aedes aegypti mosquitoes. We show that at least 4 introductions, but potentially as many as 40, contributed to the outbreak in Florida and that local transmission is likely to have started in the spring of 2016-several months before its initial detection. By analysing surveillance and genetic data, we show that ZIKV moved among transmission zones in Miami. Our analyses show that most introductions were linked to the Caribbean, a finding corroborated by the high incidence rates and traffic volumes from the region into the Miami area. Our study provides an understanding of how ZIKV initiates transmission in new regions.
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