Journal
NATURE
Volume 543, Issue 7647, Pages 637-646Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature21701
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Funding
- NSF [CHE-1361296]
- NIHGMS [R35 GM118190]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1361296] Funding Source: National Science Foundation
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Molecular recognition, binding and catalysis are often mediated by non-covalent interactions involving aromatic functional groups. Although the relative complexity of these so-called pi interactions has made them challenging to study, theory and modelling have now reached the stage at which we can explain their physical origins and obtain reliable insight into their effects on molecular binding and chemical transformations. This offers opportunities for the rational manipulation of these complex non-covalent interactions and their direct incorporation into the design of small-molecule catalysts and enzymes.
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