Related references
Note: Only part of the references are listed.Development of the First Two-Pore Domain Potassium Channel TWIK-Related K+ Channel 1-Selective Agonist Possessing in Vivo Antinociceptive Activity
Delphine Vivier et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K+ Channels
Marcus Schewe et al.
CELL (2016)
Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states
Conor McClenaghan et al.
JOURNAL OF GENERAL PHYSIOLOGY (2016)
Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs
Lin Tang et al.
NATURE (2016)
Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs
Maria V. Yelshanskaya et al.
NEURON (2016)
Novel cell-free high-throughput screening method for pharmacological tools targeting K+ channels
Zhenwei Su et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Bacterial Voltage-Gated Sodium Channels (BacNaVs) from the Soil, Sea, and Salt Lakes Enlighten Molecular Mechanisms of Electrical Signaling and Pharmacology in the Brain and Heart
Jian Payandeh et al.
JOURNAL OF MOLECULAR BIOLOGY (2015)
The family of K2P channels: salient structural and functional properties
Sylvain Feliciangeli et al.
JOURNAL OF PHYSIOLOGY-LONDON (2015)
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac
Yin Yao Dong et al.
SCIENCE (2015)
Physical mechanism for gating and mechano sensitivity of the human TRAAK K+ channel
Stephen G. Brohawn et al.
NATURE (2014)
Transmembrane Helix Straightening and Buckling Underlies Activation of Mechanosensitive and Thermosensitive K2P Channels
Marco Lolicato et al.
NEURON (2014)
Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism
Claire Bagneris et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Cation-π interactions of methylated ammonium ions: A quantum mechanical study
Chaya Rapp et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2014)
Influence of the N Terminus on the Biophysical Properties and Pharmacology of TREK1 Potassium Channels
Emma L. Veale et al.
MOLECULAR PHARMACOLOGY (2014)
A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K2P Channels
Sviatoslav N. Bagriantsev et al.
ACS CHEMICAL BIOLOGY (2013)
How good are my data and what is the resolution?
Philip R. Evans et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2013)
Better models by discarding data?
K. Diederichs et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2013)
Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel
Stephen G. Brohawn et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Activation of TREK-1 by morphine results in analgesia without adverse side effects
Maily Devilliers et al.
NATURE COMMUNICATIONS (2013)
Metabolic and thermal stimuli control K2P2.1 (TREK-1) through modular sensory and gating domains
Sviatoslav N. Bagriantsev et al.
EMBO JOURNAL (2012)
Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K+ Ion Channel
Stephen G. Brohawn et al.
SCIENCE (2012)
Crystal Structure of the Human Two-Pore Domain Potassium Channel K2P1
Alexandria N. Miller et al.
SCIENCE (2012)
Linking Crystallographic Model and Data Quality
P. Andrew Karplus et al.
SCIENCE (2012)
The pore structure and gating mechanism of K2P channels
Paula L. Piechotta et al.
EMBO JOURNAL (2011)
Multiple modalities converge on a common gate to control K2P channel function
Sviatoslav N. Bagriantsev et al.
EMBO JOURNAL (2011)
Principles of activation and permeation in an anion-selective Cys-loop receptor
Ryan E. Hibbs et al.
NATURE (2011)
Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins
David Shaya et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
MolProbity: all-atom structure validation for macromolecular crystallography
Vincent B. Chen et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)
PHENIX: a comprehensive Python-based system for macromolecular structure solution
Paul D. Adams et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)
Modulation of protein properties in living cells using nanobodies
Axel Kirchhofer et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue
Guillaume Sandoz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
A novel mechanism for human K2P2.1 channel Gating -: Facilitation of C-type gating by protonation of extracellular histidine residues
Asi Cohen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
GFP-based optimization scheme for the overexpression and purification of eukaryotic membrane proteins in Saccharomyces cerevisiae
David Drew et al.
NATURE PROTOCOLS (2008)
Up- and down-regulation of the mechano-gated K2P channel TREK-1 by PIP2 and other membrane phospholipids
Jean Chemin et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2007)
High-throughput fluorescent-based optimization of eukaryotic membrane protein overexpression and purification in Saccharomyces cerevisiae
Simon Newstead et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Fluorescence-detection size-exclusion chromatography for precrystallization screening of integral membrane proteins
T Kawate et al.
STRUCTURE (2006)
Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels
J Murbartián et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Cation-π interactions in protein-protein interfaces
PB Crowley et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2005)
BL-1249[(5,6,7,8-Tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol5-yl)-phenyl]-amine]:: A putative potassium channel opener with bladder-relaxant properties
S Tertyshnikova et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
A phospholipid sensor controls mechanogating of the K+ channel TREK-1
J Chemin et al.
EMBO JOURNAL (2005)
Searching for new allosteric sites in enzymes
JA Hardy et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2004)
Coot:: model-building tools for molecular graphics
P Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)
An intracellular proton sensor commands lipid- and mechano-gating of the K+ channel TREK-1
E Honoré et al.
EMBO JOURNAL (2002)
Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 Å resolution
YF Zhou et al.
NATURE (2001)
Multiple transport functions of a red blood cell anion exchanger, tAE1: its role in cell volume regulation
H Guizouarn et al.
JOURNAL OF PHYSIOLOGY-LONDON (2001)
TREK-1 is a heat-activated background K+ channel
F Maingret et al.
EMBO JOURNAL (2000)
Share Paper
