Journal
JOURNAL OF ESSENTIAL OIL BEARING PLANTS
Volume 21, Issue 6, Pages 1568-1584Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/0972060X.2018.1559102
Keywords
Ammodaucus leucotrichus; perillaldehyde; Toxicity; Anti-inflammatory activity; antibacterial activity
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The essential oils (EOs) of Ammodaucus leucotrichus fruits collected from four regions in Algerian Sahara were investigated for their chemical components, oil yield diversity and antibacterial property. Furthermore, the anti-inflammatory activity and the acute toxicity of these oils are herein reported for the first time. The hydrodistillated oils yielded (2.82-3.87 %) (w/w). GC and GC-MS analyses allowed us to identify twenty components representing (95.6-99.4 %). The main components were perillaldehyde (63.6-87.7 %), limonene (7.3-19.4 %) and alpha-pinene (1.2-7.9 %). The determination of the acute toxicity effect in mice showed the slight toxic nature of the EOs (LD50: 520-570 mg/kg). The oils exhibited significant anti-inflammatory effect; the inhibitions at a dose of 100 mg/kg were (18.7-24.5 %). Based on the determination of inhibition diameters, a high antibacterial activity against yeasts and gram-positive bacteria strains and a moderate activity against gram-negative bacteria strains were observed. These results indicated that A. leucotrichus EOs have promising anti-inflammatory and antibacterial properties and might be used as natural drug against inflammatory diseases or as bioactive pharmaceutical molecules.
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