Journal
NATURAL PRODUCT RESEARCH
Volume 33, Issue 5, Pages 642-650Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1402324
Keywords
Triclisia gelletii; Menispermaceae; ochnaflavone derivative; NMR chemical shift analysis; antimycobacterial activity
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Funding
- Swiss National Science Foundation (SNSF) [IZK0Z2-157272]
- Swiss National Science Foundation (SNF) [IZK0Z2_157272] Funding Source: Swiss National Science Foundation (SNF)
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Triclisinone (2), a new ochnaflavone derivative, was isolated from the aerial parts of Triclisia gilletii, along with known drypemolundein B (1) and eight other known compounds. The chemical shifts of drypemolundein B (1) have been partially revised based on reinterpretation of NMR spectroscopic data. The eight other secondary metabolites are composed of: (+)-nonacosan-10-ol (3); stigmasterol (4), 3-O-beta-D-glucopyranosylsitosterol (5), 3-O-beta-D-glucopyranosylstigmasterol (6); oleanic acid (7); myricetin (8), quercetin (9) and 3-methoxyquercetin (10). Their structures were elucidated using IR, MS, NMR 1D and 2D, H-1 and C-13 and comparison with literature data. Furthermore, compounds 1, 2, 5, 6, 8, 9 and the crude extract were tested against Mycobacterium tuberculosis. Compounds 1, 2, 8 and 9 displayed moderate to very good activity against resistant strain (codified AC 45) of M. tuberculosis with minimum inhibitory concentrations MICs ranging from 3.90 to 62.5 mu g/mL. [GRAPHICS] .
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