Journal
NATURAL PRODUCT RESEARCH
Volume 32, Issue 7, Pages 755-760Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2017.1311892
Keywords
Xylaria sp.; endophytic fungus; phthalide; antibacterial activity
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Funding
- Program for Innovative Research Team [IRT1225]
- Guangxi Natural Science Foundation of China [2014GXNSFAA 118055]
- State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University) [CMEMR2016-A06]
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A new phthalide derivative, xylarphthalide A (1), along with two known compounds (-)-5-carboxylmellein (2) and (-)-5-methylmellein (3), were isolated from the endophytic fungus Xylaria sp. GDG-102 cultured from the Chinese medicinal plant Sophora tonkinensis. Their structures were identified by MS and NMR experiments, and the absolute configuration of 1 was further confirmed by single-crystal X-ray diffraction analysis. Compound 1-3 showed antibacterial activities against Bacillus megaterium, Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Shigella dysenteriae with MIC values of 12.5-25 mu g/mL. [GRAPHICS] .
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